1988 Apr. Depending on the length of exposure, meconium skin staining may be present. Introduction. Falciglia HS, Henderschott C, Potter P, et al. Diagnosis is based on clinical presentation and chest x-ray findings. After delivery, the aspirated meconium may block the newborn's airways and cause regions of the lungs to collapse. 1. Regardless of the cause, it is vital to recognize symptoms and act quickly. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome, particularly in the presence of maternal and fetal risk factors. Preferred imaging study. Etiology of surfactant inactivation or dysfunction: pulmonary hemorrhage, sepsis, pneumonia, meconium aspiration, and post surfactant slump. ⦠The baby has passed meconium (stool) into the amniotic fluid during labor or delivery. Meconium aspiration syndrome The incidence of RDS is inversely proportional to the gestational age of the infant, with more severe disease in the smaller ⦠Meconium aspiration syndrome occurs in approximately 2% of these deliveries (1). It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. Meconium aspiration Incidence of meconium stained amniotic fluid ranges from 7-22%1 while meconium aspiration syndrome (MAS) occurs in approximately 5% of all cases of MSAF. About: Meconium aspiration syndrome It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. Meconium aspiration syndrome occurs in a small proportion of neonates whose respiratory system is contaminated by the meconium and its content. 14. Meconium Aspiration The exact pathogenesis remains unknown, but conditions that lead to fetal stress and intrauterine hypoxia seem to be the most important risk factors. Meconium-stained amniotic fluid and meconium aspiration syndrome: an update. Does DeLee suction at the perineum prevent meconium aspiration syndrome? Therefore, MAS has a wide range of severity depending on what ⦠Symptoms of Anoxia and Hypoxia. Characterize meconium aspiration syndrome (MAS). The PowerPoint PPT presentation: "Meconium Aspiration Syndrome" is the property of its rightful owner. MAS may occur if the baby breathes in (aspirates) this fluid into the lungs. After suction, the baby was given 100% oxygen and his respirations were supported. Although anecdotal data concerning the efficacy of intrapartum oropharyngeal and nasopharyngeal suctioning of MSAF are conflicting, the procedure is widely used. BACKGROUND Meconium aspiration syndrome (MAS) is a life-threatening respiratory disorder in infants born through meconium-stained amniotic fluid (MSAF). Share yours for free! Meconium aspiration syndrome in a term baby. The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents.The Journal publishes original work based on standards of excellence and expert review. Learn new and interesting things. The severity of meconium aspiration syndrome and mortality were also related to the clinical stability of the infants at presentation. Severe meconium aspiration syndrome. Although most aspirations occur in utero, postnatal aspiration may also lead to development of MAS. The Association for Academic Surgery is widely recognized as an inclusive surgical organization. NURSING CARE PLAN Inefective Infant Feeding ASSESSMENT. MAS can present with varying degrees of severity from mild respiratory distress to life-threatening respiratory failure. ASPIRATION PNEUMONIA NEWBORN CASE STUDY CONCEPT MAP PATHOPHYSIOLOGY ⢠During delivery, perhaps 5% of neonates with The normal fetal hemoglobin oxygen saturation is ⦠3-8 The case fatality rate of the meconium aspiration syndrome is ⦠CK Natarajan, et al Surfactant therapy and antibiotics in neonates with meconium aspiration syndrome: a systematic review and meta-analysis Journal of Perinatology (2016) 36, S48âS53. When meconium is passed in utero and mixed with amniotic fluid, the baby may inhale, or aspirate, the meconium-stained fluid. Clinical Presentation. CASE PRESENTATION Baby C was immediately intubated and suctioned for a large amount of meconium. Ghidini A, Spong CY. Meconium aspiration 10. Introduction. 2001 Oct. 185 (4):931-8. . RDS in a premature infant is defined as respiratory distress requiring more than 30% ⦠Features of severe meconium aspiration. The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery.The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, pathology and surgical ⦠MAS can have serious ⦠Meconium aspiration syndrome Abstract Meconium aspiration syndrome (MAS) is one of the most common conditions associated with aspiration during the newborn period. The signs and symptoms of meconium aspiration syndrome include: 1. Meconium is the first stool of an infant. OBJECTIVES: Inability of the infant to suck effectively (poor sucking reflex) Inability to coordinate sucking, swallowing and breathing Inconsistent oral intake Regurgitation after feeding AOG of 30 weeks feeling limp when held Poor skin turgor Sunken DIAGNOSIS. Meconium aspiration syndrome (MAS) refers to breathing problems that a newborn baby may have when: There are no other causes, and. Case contributed by Dr Jeremy Jones Diagnosis probable Diagnosis probable . Pleural effusions 2. The baby has passed meconium (stool) into the amniotic fluid during labor or delivery. Surfactant replacement therapy for RDS - Early rescue therapy should be practiced: First dose needs to be given as soon as diagnosis of RDS is made. Severe meconium aspiration syndrome is not caused by aspiration of meconium. After ⦠Green urine may be observed in newborns with meconium aspiration syndrome less than 24 hours after birth. Up to 10-15% of live births after 34 weeks can present with meconium stained fluid but only 1-5% of neonates develop meconium aspiration. This activity describes the pathophysiology, presentation, and management of meconium aspiration syndrome and highlights the importance of an interprofessional team approach in improving care for and decreasing morbidity in patients with this condition. Meconium Aspiration Page 3 of 9 6.1.10 o ENT: Meconium seen on cords if endotracheal intubation/suction performed o Respiratory: Tachypnea, retractions, grunting, nasal flaring, coarse bilateral rhonchi o CV: May have murmur, cyanosis o Dermatologic: Skin, nails and umbilical cord may be meconium-stained . The impetus of the membership remains research-based academic surgery, and to promote the shared vision of research and academic pursuits through the exchange of ideas between senior surgical residents, junior faculty and established academic ⦠10. Introduction. The aspiration of meconium can occur before or during labor and immediately after delivery. Aspiration can occur in utero with foetal gasping, or after birth, with the first breaths of life Meconium aspiration syndrome (MAS) is defined as a respiratory distress that develops shortly after birth, with radiographic evidence of aspiration pneumonitis and presence of meconium stained amniotic fluid . (MAS) refers to a varying spectrum of respiratory distress in neonates born through meconium-stained liquor. Clinical presentation includes tachypnea and respiratory distress with cyanosis. Pneumothorax 3. Meconium contamination of amniotic fluid occurs in 10â15% of all pregnancies, and 5â10% of these infants develop meconium aspiration syndrome and respiratory failure . When infants are born through thin meconium and are vigorous at birth, respiratory complications are minimal. The history of meconium at delivery confirms the diagnosis, but the imaging findings are classical. Defined as respiratory distress in the newborn due to the presence of meconium in the trachea. For example, the chest radiograph may be initially marked by patchy parahilar consolidation associated with aspiration of particulate meconium, but subsequent pro- When this happens, the sphincter can relax and move meconium into the amniotic fluid. 4. Neonatal sepsis may be categorized as early-onset or late-onset. Our results indicate that intrauterine aspiration and pulmonary maladaptation may play a significant role in meconium aspiration syndrome rather than resuscitative events at delivery. Some include chemical induced inflammation of the lungs as a subtype, which occurs from acidic but non-infectious stomach ⦠After delivery, the aspirated meconium may block the newborn's airways and cause regions of the lungs to collapse. L/S ratio was 1.5:1 If meconium is passed more than 4 hours before delivery, the infant's skin will be meconium stained. Causes. Hyaline membrane 1. Knowledge of association of various maternal and fetal factors with meconium aspiration syndrome is important to know and understand to timely judge the outcome and take The presence of meconium in amniotic fluid is required to cause meconium aspiration syndrome (MAS), but not all neonates with meconium-stained fluid develop this condition. Meconium aspiration syndrome happens when the newborn displays respiratory distress caused by the ingestion and aspiration of meconium. Meconium aspiration syndrome is a pulmonary complication appearing in newborns with a meconium-stained amniotic fluid. Clinical presentation includes tachypnoea and respiratory distress with cyanosis. Meconium aspiration syndrome (MAS) is defined as respiratory distress in a neonate born through meconium-stained amniotic fluid (MSAF) having characteristic radiological changes whose symptoms cannot be otherwise explained. Student Nurses Community. The passage of meconium in to the amniotic ï¬uid and its consequences are a multifactorial process which is affected by multiple factors associated with fetus as well as mother. Does DeLee suction at the ⦠Green urine may be observed in newborns with meconium aspiration syndrome less than 24 hours after birth. Meconium does not usually develop before 34 weeksâ gestation, so this is usually found in babies born at term. Meconium is the first intestinal discharge from newborns, a viscous, dark-green substance composed of intestinal epithelial cells, lanugo, mucus, and intestinal secretions Lobar emphysema 4. Meconium staining may be visible in the oropharynx and (on intubation) in the larynx and trachea. https://www.winchesterhospital.org/health-library/article?id=840525 10. Difficult labor and delivery. ... Clinical presentation of infants born in meconium-stained amniotic fluid can depend on the consistency of the meconium. Defined as respiratory distress in the newborn due to the presence of meconium in the trachea. View Meconium Aspiration Syndrome.ppt from MEDICINE PEDIATRICS at University of Colombo. Release of meconium into the amniotic fluid is usually the result of in utero hypoxia and/or fetal distress. Pneumonias 1. Arch Dis Child. When the brain has been deprived of oxygen for a certain amount of time, the brain goes into emergency mode and starts operating at a rapid speed until it starts malfunctioning. X-ray. Meconium Aspiration Syndrome (MAS) is the term used to describe a spectrum of disorders, marked by various degrees of respiratory distress in the new born infant.This follows the aspiration of meconium stained amniotic fluid (MSAF), which can happen either antenatally (2.8% of all pregnancies) or during birth (up to 23% of all pregnancies) (1). The Journal seeks to publish high ⦠It is a sign that there has been some fetal distress. Case contributed by Dr Jeremy Jones Diagnosis probable Diagnosis probable . If so, share your PPT presentation slides online with PowerShow.com. The history of meconium at delivery confirms the diagnosis, but the imaging findings are classical. Incidence is 2-10% of infants born through MSAF (meconium-stained amniotic fluid) Thought to be associated with fetal hypoxia and post-term delivery. Aspiration pneumonitis and pneumonia are caused by inhaling toxic and/or irritant substances, usually gastric contents, into the lungs. No pneumothorax. Mass lesions 3. A âgaspâ happens when the baby is 1 in 2000 of all pregnancies).2 ⦠MECONIUM ASPIRATION SYNDROME Definition This is a severe pulmonary disease characterized by chemical pneumonitis and mechanical obstruction of the airways. Patient Data. Introduction. Meconium aspiration syndrome. Meconium stained amniotic fluid (MSAF) is an alarming sign of fetal compromise and associated with a poor perinatal outcome. Diffuse consolidation and airspace change in both lungs, most pronounced in the upper lobes. Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. The variable clinical presentation of MAS is basically connected with variation of the amount and consistency of aspirated meconium and also its distribution within the affected lungs. Quizlet is the easiest way to study, practice and master what youâre learning. Clear fluid aspiration 11. Our results indicate that intrauterine aspiration and pulmonary maladaptation may play a significant role in meconium aspiration syndrome rather than resuscitative events at delivery. Complications may include lung abscess. meconium aspiration syndrome and respiratory failure (4). Meconium aspiration syndrome 4. Aspiration of amniotic fluid with meconium represents one of the causes of disease and mortality of new-borns, but also poses one of the problems for forensic expertise in malpractice cases. Meconium aspiration syndrome (MAS) refers to a varying spectrum of respiratory distress in neonates born through meconium-stained liquor. Meconium stained liquor. Feb 9, 2018 - Explore Rebecca Almanza's board "Meconium Aspiration Syndrome", followed by 134 people on Pinterest. Aspiration: Breathing something into the lungs. Patient Data. Aspiration of meconium by the fetus, leading to chemical pneumonitis and mechanical obstruction of bronchi after delivery. Presentation. [3, 7, 4, 8] However, the inflammatory process of meconium aspiration may have various presentations on chest radiography, and it is initially indistinguishable from transient tachypnea of the newborn or neonatal pneumonia.Without visualization of meconium below the vocal cords during ⦠What is meconium aspiration syndrome? and the meconium aspiration syndrome complicates 1.7 to 35.8 percent of these deliveries. It is sometimes passed into the fluid that surrounds the baby in the womb. Patient Data. Infants with MAS are usually post-mature, or have experienced intrauterine stress. The severity of meconium aspiration syndrome and mortality were also related to the clinical stability of the infants at presentation. Vocal cord paralysis 8. MAS may occur if the baby breathes in (aspirates) this fluid into the lungs. Although most aspirations occur in utero, postnatal aspiration may also lead to development of MAS. Severe meconium aspiration syndrome. Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. Meconium liquor or meconium stained liquor is the stained amniotic fluid that most members of the health team can recognize as a clinical symptom of fetal distress. Meconium staining can place a newborn baby at risk for a condition known as the meconium aspiration syndrome. Meconium does not usually develop before 34 weeksâ gestation, so this is usually found in babies born at term. Meconium aspiration syndrome occurs when stress (such as infection or low oxygen levels) causes the fetus to take forceful gasps, so that the amniotic fluid containing meconium is breathed (aspirated) in and deposited into the lungs. Meconium Aspiration Syndrome. Meconium aspiration syndrome occurs in approximately 2% of these deliveries (1). Features of severe meconium aspiration. Difficult labor and delivery. Black race, 3. Objectives: Describe the etiology of meconium aspiration syndrome. The most common cause of pneumothorax is from air delivered by a breathing machine (mechanical ventilator). A baby born with a lung disease may need to be on a breathing machine. Another cause is meconium aspiration. This is when a baby is still in the motherâs womb and breathes in its first stool (meconium). Although most aspirations occur in utero, postnatal aspiration may also lead to development of MAS. Aspirated meconium can interfere with normal breathing by several mechanisms including airway obstruction, chemical irritation, infection and surfactant inactivation and induces more or less severe signs of respiratory distress at birth. f Meconium aspiration syndrome (MAS) is the aspiration of stained amniotic fluid, which can occur before, during, or immediately after birth. The thick, tenacious meconium causes obstruction of small- and medium-sized airways, which leads to areas of both atelectasis and overinflation. If meconium is passed more than 4 hours before delivery, the infant's skin will be meconium stained. When meconium is passed in utero and mixed with amniotic fluid, the baby may inhale, or aspirate, the meconium-stained fluid. The clinical presentation of meconium aspiration syndrome can be quite variable. 3. Review prevention measures and treatment of MAS. Meconium: First stool-if expelled prior to delivery it is present in amniotic fluid. Meconium-stained amniotic fluid occurs in 7 to 22 percent of term deliveries, 1,2 and the meconium aspiration syndrome complicates 1.7 to 35.8 percent of ⦠Not all infants who inhale meconium will have MAS. Do you have PowerPoint slides to share? A meconium aspiration syndrome, another was thought to controlled multivariate analysis of selected outcomes did have aspirated clear amniotic fluid, and the fifth had evi- not reveal any additional significant associations (Table 3). Presentation. Meconium aspiration syndrome occurs when stress (such as infection or low oxygen levels) causes the fetus to take forceful gasps, so that the amniotic fluid containing meconium is breathed (aspirated) in and deposited into the lungs. Am J Obstet Gynecol. Pulmonary Airleak syndromes 5. Get ideas for your own presentations. Meconium aspiration syndrome is a serious condition in which a newborn breathes a mixture of meconium and amniotic fluid into the lungs around the time of delivery. DefinitionDefinition Meconium aspiration syndromeMeconium aspiration syndrome (MAS) is a respiratory distress in an (MAS) is a respiratory distress in an infant born throughinfant born through Meconium stained amniotic fluidMeconium stained amniotic fluid whose symptoms cannot bewhose symptoms cannot be otherwise explained.otherwise explained. Thick meconium Meconium aspiration syndrome (MAS) is an acute chemical was noted at delivery. Meconium aspiration syndrome develops in 1.8 to 18 percent of infants delivered from meconium-stained amniotic fluid and is associated with ... establish dilatation and confirm presentation. Presentation ranges from mild respiratory distress to life-threatening respiratory failure. Explain the pathophysiology that occurs after meconium aspiration. Depending on the length of exposure, meconium skin staining may be present. His 5 minute Apgar score was 5, with acrocyanosis and grunting respirations. This can cause breathing difficulties due to swelling (inflammation) in the baby's lungs after birth. Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Meconium Aspiration Syndrome Many are downloadable. meconium aspiration syndrome and respiratory failure (4). View Test 1 Meconium Aspiration PPT.pptx from RNSG 1430 at San Antonio College. If a mother's amniotic fluid appears to have meconium, a technique called amnioinfusion may be used during labor. MAS contributes to neonatal death in up to 0.05% (i.e. Meconium aspiration syndrome (MAS) refers to breathing problems that a newborn baby may have when: There are no other causes, and. Meconium is the first feces, or stool, of the newborn. Meconium Aspiration Syndrome Overview""Meconium Aspiration Syndrome Pipeline Insight, 2020"" Report By DelveInsight Outlays Comprehensive Insights Of Present Clinical Development Scenario And Growth Prospects Across The Meconium Aspiration Syndrome Market.A Detailed Picture Of The Meconium Aspiration Syndrome Pipeline Landscape Is Provided, Which Includes ⦠2. Infants usually start their bowel movement after birth. Figure 33B. 1, 2 MAS accounts for about 10% of cases of respiratory failure in all neonates, and is associated with significant morbidity ⦠Meconium Aspiration Syndrome Definition. However, in some instances, they start producing meconium, their first stool, while still inside the motherâs womb. Introduction. (Meconium pigments can be absorbed by the lungs and can be excreted in urine). Signs: Severe respiratory distress may be present. Age: 2 days Gender: Female From the case: Meconium pneumonitis. Mekonium dapat keluar di dalam kandungan bila terjadi stres /kegawatan intrauterin.Mekonium yang terhirup bisa menyebabkan penyumbatan parsial ataupun total pada saluran pernafasan, sehingga terjadi ⦠More than 50 million students study for free with the Quizlet app each month. Inadequate removal of meconium from the airway prior to the first breath and use of positive pressure ventilation (PPV) prior to clearing the airway of meconium increase the likelihood of a neonate developing meconium aspiration syndrome. Le méconium est un excrément accumulé dans les intestins du foetus des mammifères (dont l'humain) durant sa gestation et constitue les premières selles du nouveau-né, pendant les premiers jours qui suivent la naissance.. Chez les insectes holométaboles, le méconium est un fluide fécal accumulé lors de la métamorphose, que l'adulte vide après lâémergence de sa nymphe [1]. Meconium stained liquor. View Meconium Aspiration Syndrome PPTs online, safely and virus-free! Clinical presentation. Mekonium aspiration syndrome Sindroma aspirasi mekonium merupakan sekumpulan gejala yang diakibatkan oleh terhisapnya mekonium ke dalam saluran pernafasan bayi. Review the presentation and clinical features of meconium aspiration syndrome. There is commonly a history of meconium stained fluid at birth. RDS primarily affects preterm neonates, and infrequently, term infants. The Apgar scores were 1 at 1 minute and pneumonitis with consequent disruption of the alveolarcapillary 5 minutes, and 4 at 10 minutes. Defined as respiratory distress in the newborn due to the presence of meconium in the trachea. Tachypnea, grunting, and respiratory insufficiency are the main ⦠Signs and symptoms often include fever and cough of relatively rapid onset. Pulmonary function in children after neonatal meconium aspiration syndrome. Lingual thyroid 9. Introduction MAS in the newborn is characterized by hypoxia, hypercap-nia, and acidosis. Meconium Aspiration: Meconium that has been released prior to delivery in amniotic fluid is aspirated prior to delivery or with their first breath. Male fetus, 4. Falciglia HS, Henderschott C, Potter P, et al. Jaundice is t he yellow colouring of skin and sclera caused by the accumulation of bilirubin in the skin and mucous membranes.. Neonatal jaundice occurs in 60% of term infants and 80% of preterm infants [1] and is caused by hyperbilirubinaemia that is unconjugated (divided into physiological or pathological) or conjugated (always pathological). The clinical presentation can vary from mild respiratory distress through to severe respiratory failure, which cannot be explained by an alternative diagnosis. 1. Release of meconium into the amniotic fluid is usually the result of in utero hypoxia and/or fetal distress. Outline the importance of interprofessional team strategies for improving care coordination and communication to advance the care of meconium aspiration syndrome and improve outcomes. Identify the complications associated with meconium aspiration syndrome. Frontal Endotracheal tube. Treatment may include suctioning the newborn's mouth as soon as the head emerges during delivery, deep ⦠Meconium aspiration syndrome occurs in a small proportion of neonates whose respiratory system is contaminated by the meconium and its content. Neonatal respiratory distress syndrome, or RDS, is a common cause of respiratory distress in a newborn, presenting within hours after birth, most often immediately after delivery. A term newborn presented with respiratory distress at birth and meconium-stained fluid. Tachypnea, grunting, and respiratory insufficiency are the main ⦠The clinical presentation of meconium aspiration syndrome can be quite variable. Meconium Aspiration Syndrome Case 1 ⢠⢠⢠⢠DOB 14/5/04 ⦠The frequency of meconium presence in amniotic fluid is 5 - 22%, the aspiration of amniotic fluid occurs in around 10 â 15 % new-borns, where 2 - 10 % of them develop meconium aspiration syndrome [1 ⦠Meconium Aspiration Syndrome By: Erica Cowan Stress on a fetus may cause a decrease in oxygen, which in turn results in an increase in intestinal activity. Symptoms include cough and dyspnea. About the Societies. Meconium aspiration syndrome. It is possible to die from aspiration pneumonia so doctors will address the condition as soon as possible. Doctors will give special consideration to each personâs treatment to ensure they receive the correct antibiotic. Life-threatening complications might occur if the person has gone too long without treatment or has a compromised immune system. Aspiration pneumonia is a type of lung infection that is due to a relatively large amount of material from the stomach or mouth entering the lungs. The exact pathogenesis remains unknown, but conditions that lead to fetal stress and intrauterine hypoxia seem to be the most important risk factors. Macfarlane PI, Heaf DP. Meconium can make it harder to breathe because it can:clog the airwaysirritate the airways and injure lung tissueblock surfactant, a fatty substance that helps open the lungs after birth Aspiration pneumonitis? [1] The spectrum of manifestations associated with meconium aspiration is broad, ranging from mild distress to more severe respiratory failure. Chest radiography is the preferred examination. See more ideas about syndrome, aspire, nicu nurse. dence of meconium aspiration although none was seen dur- ing labour. Meconium aspiration syndrome occurs when a The clinical presentation of meconium aspiration syndrome can be quite variable. Risk factorsThere are a number of factors associated with an increased risk of developing MAS; these include a: 1. History Presence of meconium in amniotic fluid. 1. Ineffective infant feeding ⦠Signs of meconium aspiration syndrome include tachypnea, nasal flaring, retractions, cyanosis or desaturation, rales, rhonchi, and greenish yellow staining of the umbilical cord, nail beds, or skin. Meconium staining may be visible in the oropharynx and (on intubation) in the larynx and trachea. Create your own flashcards or choose from millions created by other students. The clinical presentation of meconium aspiration syndrome can be quite variable. Meconium is a dark green fecal material produced in the intestines of a fetus before birth. Clinical presentation includes tachypnea and respiratory distress with cyanosis. Falciglia HS, Henderschott C, Potter P, et al. There is commonly a history of meconium stained fluid at birth. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, ⦠Meconium aspiration syndrome (MAS) is defined as respiratory distress in newborn infants born through meconium-stained amniotic fluid (MSAF) whose symptoms cannot be otherwise explained. After meconium gets into the amniotic fluid, the infant may breathe it into the lungs. 3. CK Natarajan, et al Surfactant therapy and antibiotics in neonates with meconium aspiration syndrome: a systematic review and meta-analysis Journal of Perinatology (2016) 36, S48âS53. Meconium aspiration syndrome decreased nearly four-fold from 1990-1992 to 1997-1998 (5.8% to 1.5% of meconium-stained infants more than 37 weeks; P <.003). 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